Popular spots include Travellers Inn, known for its bustling Friday nights, and The Pier Hotel, famous for its "Thirsty Thursday" events offering drinks, dinner, and pool games. Taylor St Quarters appeals to music enthusiasts with its live music offerings, while The Esperance and The Snakepit Nightclub provide energetic atmospheres with live music and late-night entertainment. Taylor's Beach Bar & Cafe offers a laid-back setting for enjoying live performances and socializing, while Condigup Tavern, a family-owned venue located 20 km from Duke of Orleans Bay Caravan Park and Wharton's Beach, exudes a relaxed, rustic charm.
Beyond these regular venues, Esperance also hosts occasional special events such as pool parties, discotheques, DJ nights, and pub crawls, contributing to the diversity and vibrancy of the nightlife scene.